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The carefully calibrated andropause formula in Provacyl™ has been optimized, based on the most current emerging medical research into anti-aging.
Here is a sampling of the DOZENS of peer-reviewed scientific studies, trials, and articles that have appeared in prestigious medical journals over the past few years including studies that support the individual ingredients included in the Provacyl™ formula.
“The effects of six months of human growth hormone on lean body mass and adipose-tissue were equivalent in magnitude to the changes incurred during 10-20 years of aging.”
Daniel Rudman, M.D., in the New England Journal of Medicine
Provacyl™ Ingredient: Dehydroepiandrosterone (DHEA)
“Replacing GH, or stimulating GH with GH-releasing hormone or a GH secretagogue could confer benefits in normal aging… in particular, could reduce the loss of muscle mass, strength, and exercise capacity leading to frailty, thereby prolonging the ability to live independently.
… Preliminary reports of improved cognition are encouraging…”
Hersch EC, Merriam GR.
Clin Interv Aging. 2008;3(1):121-9.
“Replacement therapy with Growth Hormone has shown beneficial/normalizing effect on parameters such as cardiac and renal function, thyroid hormone metabolism, bone metabolism, sweat secretion, total and regional fuel metabolism and psychological well being.”
Dr. Jorgensen and Dr. Christian of Copenhagen, Denmark
European Journal of Endocrinology, 1994
“Indirect evidence suggests that GH are of importance in developing muscle strength because young adults with GH deficiency have reduced muscle mass and strength.”
Lancet 1989; i: 1221-1225
“Beneficial effect of growth hormone treatment in GH-deficient adults.”
“GH therapy improved the QOL [quality of life] similarly in elderly GH-deficient patients and younger counterparts.”
Clin Endocrinol (Oxf) 2000;53:281-289
"Many animal and human studies show that supraphysiological doses of dehydroepiandrosterone (DHEA) can influence body composition and carbohydrate and lipid metabolism."
DHEA Replacement in Healthy Men with Age-Related Decline of DHEA-S
The Aging Male (Journal), 2003; 6(3):151-156
"Administration of oral DHEA at a daily dose of 50 mg to age-advanced men with low serum DHEAS levels significantly activated immune function."
Activation of Immune Function by Dehydroepiandrosterone (DHEA) in Age-Advanced Men;
The Journals of Gerontology, 1997; 52A(1):M1-M7
"DHEA treatment may have significant antidepressant effects in some patients with major depression. Further, larger-scale trials are warranted."
Double-Blind Treatment of Major Depression With Dehydroepiandrosterone
American Journal of Psychiatry; 1999 April; 156:646-649
"DHEA may be useful in treating age-related central nervous system diseases based on its protective effects in the hippocampus."
DHEA Protects Hippocampal Cells from Oxidative Stress-Induced Damage
Molecular Brain Research, 1999 March; 66(1-2):35-41
"This pilot study suggests that dehydroepiandrosterone is an effective treatment for midlife-onset dysthymia."
Dehydroepiandrosterone Treatment of Midlife Dysthymia
Molecular Brain Research, 1999 March; 66(1-2):35-41
"DHEA replacement could play a role in prevention and treatment of the metabolic syndrome associated with abdominal obesity."
Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men:
Journal of the American Medical Association, 2004; 292(18):2243-2248
"In both studies, improvements in depression ratings and memory performance were directly related to increases in plasma levels of DHEA and DHEA-S and to increases in their ratios with plasma cortisol levels. These preliminary data suggest DHEA may have antidepressant and promemory effects and should encourage double-blind trials in depressed patients."
DHEA and Treatment of Depression
Biological Psychiatry, 1997 February; 41(3):311-318
"It should be pointed out that chronic inflammation is known to play a critical role in the development of the killer diseases of aging: heart disease, Alzheimer’s disease and certain types of cancer. In conclusion, DHEA or DHEAS administration combined with conventional treatment may be implicated in particular conditions to improve the quality of life."
DHEA(S): The Fountain of Youth
Journal of the Medical Associate of Thailand, 1984 October; 2:605-612
"With the passage of the U.S. Dietary Supplement Health and Education Act of 1994, dehydroepiandrosterone (DHEA, 5-androsten-3ß-ol-17-one) has become widely available, and a large and growing market has developed for this “fountain of youth”. DHEA has been shown to have significant beneficial effects in animals, which may lead to clinical uses in man."
The Effects of DHEA on Carcinogenesis, Obesity, the Immune System, and Aging
LIPIDS; 35(3):325-331
“Average lifespan compared with that of untreated rats was increased and general condition, judged by observation, was improved by treatment. The dose of posterior pituitary powder was modest since it did not affect body weight and in a 48-hr balance study produced only a minimal antidiuretic effect. Even so, it was quite sufficient to produce a significant improvement in the ability of the indirectly stimulated gastrocnemius to perform work as measured isometrically. Further, treatment was quite sufficient to suppress to a significant degree the increase of weight of kidney, heart, adrenal and pituitary ordinarily associated with aging.”
Prolonged Treatment with Pituitary Powder in Aged Rats
Experimental Gerontology, 1964 July;1(1):37-48
"We conclude that in healthy very old age endothelial function is impaired and may be improved by oral L-arginine supplementation, probably due to normalization of the L-arginine/ADMA ratio."
Oral L-arginine Improves Endothelial Function in Healthy Individuals Older Than 70 Years Vascular Medicine,
2003 May;8(2):77-81
"Long-term oral administration of supra-physiologic doses of L-arginine improves the erectile response in the aging rat. We postulate that L-arginine in the penis may be a substrate-limiting factor for NOS activity and that L-arginine may up-regulate penile NOS activity but not its expression."
Effects of Long-term Oral Administration of L-Arginine on the Rat Erectile Response
The Journal of Urology, 1997 September;158(3):942-947
"It is now well documented that under appropriate conditions, glutamine is essential for cell proliferation, that it can act as a respiratory fuel and that it can enhance the function of stimulated immune cells."
Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection? – Journal of Nutrition, 2001 September;131(9):2515S-2522S
"EGb (Ginko Biloba) was safe and appears capable of stabilizing and, in a substantial number of cases, improving the cognitive performance and the social functioning of demented patients for 6 months to 1 year. Although modest, the changes induced by EGb were objectively measured by the ADAS-Cog and were of sufficient magnitude to be recognized by the caregivers in the GERRI."
A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia; Journal of the American Medical Association, 1997;278(16):1327-1332
"The clinical efficacy of the ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type and multi-infarct dementia was confirmed. The investigational drug was found to be well tolerated."
Efficacy of the Ginkgo Biloba Special Extract EGb 761 in Outpatients Suffering from Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Multi-infarct Dementia Pharmacopsychiatry, 1996;29(2):47-56
"Positive results have been reported for Ginkgo biloba extracts in the treatment of cerebral insufficiency. The clinical evidence is similar to that of a registered product which is prescribed for the same indication."
Ginko Biloba for Cerebral Insufficiency
British Journal of Clinical Pharmacology, 1992 October;34(4):352–358
"(Results) represented an average improvement of 7.5% and reflected improvements to a number of different aspects of memory, including working and long-term memory. This enhancement to memory was seen throughout the 12-week dosing period and also after a 2-week washout. This represents the first substantial demonstration of improvements to the memory of healthy middle-aged volunteers produced by a phytopharmaceutical."
The Memory Enhancing Effects of a Ginkgo Biloba/Panax Ginseng Combination in Healthy Middle-Aged Volunteers; Psychopharmacologia , 2000;152(4):353-361
"These data are additional to the antioxidant properties of EGb 761 reported in the literature and indicate a possible role for the extract in the treatment of diseases involving free radicals and oxidative damage."
The Antioxidant Activity of Standardized Extract of Ginkgo Biloba (EGb 761) in Rats
Phytotherapy Research, 2001 August;15(5):449-451
"Because of its dopaminergic effect, Agnus castus could be considered as an efficient alternative phytotherapeutic drug in the treatment of slight hyperprolactinaemia (which can lead to erectile dysfunction)."
Agnus Castus Extracts Inhibit Prolactin Secretion of Rat Pituitary Cells
Hormone and Metabolic Research, 1993;25(5):253-255
"These data suggest that VACF (angus-castus fruits) contains components that inhibit proliferation and induce apoptosis in human prostate epithelial cell lines. The extract may be useful for the prevention and/or treatment not only of benign prostatic hyperplasia but also of human prostate cancer."
A Vitex Agnus-Castus Extract Inhibits Cell Growth and Induces Apoptosis in Prostate Epithelial Cell Lines Planta Medica,
2005;71(10):910-916
"Antioxidant-rich berries consumed in the diet can positively impact learning and memory in the aged animal. This effect on cognition is thought to be due to the direct interaction of berry polyphenols with aging neurons, reducing the impact of stress-related cellular signals and increasing the capacity of neurons to maintain proper functioning during aging."
Recent Advances in Berry Supplementation and Age-Related Cognitive Decline
Current Opinions in Clinical Nutrition and Metabolic Care. 2009 Jan;12(1):91-4.
"Among people aged 65 and older, higher ascorbic acid and beta-carotene plasma level are associated with better memory performance. These results indicate the important role played by antioxidants in brain aging and may have implications for prevention of progressive cognitive impairments."
The Relation Between Antioxidants and Memory Performance in the Old and Very Old; Perrig WJ, Perrig P, Stähelin HB, Institute of Psychology, University of Berne, Switzerland.
"Several laboratories, including our own, have shown that antioxidants preserve an adequate function of immune cells against homeostatic disturbances caused by oxidative stress, such as that involved with age. Therefore, since the immune system is an indicator of health and a longevity predictor, the protection of this system afforded by dietary antioxidant supplementation may play an important role in order to achieve a healthy aging.
Effects of Antioxidants on Immune System Ageing
European Journal of Clinical Nutrition, 2002 Aug;56 (Suppl 3):S5-8.
"Our data show that Korean red ginseng can be as effective alternative for treating male erectile dysfunction."
A Double-Blind Crossover Study Evaluating the Efficacy of Korean Red Ginseng in Patients With Erectile Dysfunction: A Preliminary Report
The Journal of Urology, 2002 November;168(5):2070-2073
"In the group receiving ginseng, changes in early detumescence and erectile parameters such as penile rigidity and girth, libido and patient satisfactions were significantly higher than that of other groups (p < 0.05). The overall therapeutic efficacies on erectile dysfunction were 60% for ginseng group and 30% for placebo and trazodone treated groups, statistically confirming the effect of ginseng (p < 0.05). No complete remission of erectile dysfunction was noted, but partial responses were reported. No cases of aggravation of symptoms were reported."
Clinical Efficacy of Korean Red Ginseng for Erectile Dysfunction
International Journal of Impotence Research, 1995 Sep;7(3):181-6.
"Ginseng is the root of the perennial herbs of Panax quinquefolium and Panax ginseng which contain a series of tetracyclic triterpenoid saponins (ginsenosides) as active ingredients. It is considered a tonic or adaptogenic that enhances physical performance (including sexual), promotes vitality and increases resistance to stress and ageing. The adaptogenic properties of ginseng are believed to be due to its effects on hypothalamic–pituitary–adrenal axis, resulting in elevated plasma corticotropin and corticosteroids levels."
The Aphrodisiac and Adaptogenic Properties of Ginseng
Fitoterapia, 2000 August;71(S1):S1-S5
"Korean Panax ginseng C A Meyer is mainly used to maintain the homeostasis of the body, and the pharmacological efficacy of Korean ginseng identified by modern science includes improved brain function, pain-relieving effects, preventive effects against tumors as well as anti-tumor activity, enhanced immune system function, anti-diabetic effects, enhanced liver function, adjusted blood pressure, anti-fatigue and anti-stress effects, improved climacteric disorder and sexual functions, as well as anti-oxidative and anti-aging effects."
Botanical Characteristics, Pharmacological Effects and Medicinal Components of Korean Panax Ginseng; Acta Pharmacologica Sinica, 2008 September;29(9):1109–1118.
"Panax ginseng can improve performance and subjective feelings of mental fatigue during sustained mental activity. This effect may be related to the acute gluco-regulatory properties of the extract."
Single Doses of Panax Ginseng (G115) Reduce Blood Glucose Levels and Improve Cognitive Performance During Sustained Mental Activity
J Psychopharmacol 2005 July;19(4):357-365
"Findings suggest that KRG has a hypotensive effect and its effect may be due to saponin fraction of KRG in the conscious rats. The releasing effect of NO of KRG, like NO donor, may be partly contributed to the hypotensive effect of KRG."
Effect of Korea Red Ginseng on the Blood Pressure in Conscious Hypertensive Rats
General Pharmacology: The Vascular System, 2000 September;35(3):135-141
"The present study further supports the folk use of E. longifolia jack as an aphrodisiac."
Eurycoma Longifolia Jack and Orientation Activities in Sexually Experienced Male Rats; Biological and Pharmaceutical Bulletin, 1998 Feb;21(2):153-5
"The results showed that E. longifolia produced a dose-dependent, recurrent and significant increase in the episodes of penile reflexes as evidenced by increases in quick flips, long flips and erections of the treated male rats during the 30 min observation period. These results provide further evidence that E. longifolia increases the aphrodisiac potency activity in treated animals."
Evaluation of the Potency Activity of Aphrodisiac in Eurycoma Longifolia Jack
Phytotherapy Research, 2001 August;15(5):435–436
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